There may be one notable threat related to this drug: Mavacamten can improve your threat of coronary heart failure.
“As a result of mavacamten decreases coronary heart muscle contraction, there’s a chance that the center muscle might overreact to it, growing the chance of the center turning into too weak,” Makkiya says.
Mavacamten is just accessible as a part of a threat analysis and mitigation technique (REMS) program, which requires ongoing monitoring to make sure you aren’t growing coronary heart failure. This makes getting a prescription extra complicated, because it requires you and your heart specialist to be enrolled within the REMS program.
Your heart specialist will:
- Consider your coronary heart failure threat with an echocardiogram
- Assess your current medicines to rule out interactions with mavacamten. Taking diltiazem, disopyramide (Norpace), ranolazine, rifampin, or verapamil with a beta-blocker can improve your threat of coronary heart failure or heart-rhythm issues, for instance.
- Verify your coronary heart operate with echocardiograms repeatedly. These are required to proceed or improve mavacamten dosages.
Just one p.c of mavacamten customers within the REMS program have skilled coronary heart failure.
“When prescribed appropriately inside [REMS], mavacamten could be very protected, and dose changes can stop long-term issues,” Makkiya says.
