Can Topiramate (Topamax) Assist You Lose Weight?

Does Off-Label Topiramate Assist Weight Administration?

A number of research have demonstrated how topiramate will help with weight reduction. One randomized managed trial in contrast topiramate to a placebo in 385 sufferers ages 18 to 75 with a physique mass index (BMI) between 30 and 50. The sufferers who got topiramate took 4 doses ranging between 64 and 384 milligrams. The research discovered that each one 4 doses led to important weight reduction in contrast with the placebo group, with increased doses akin to larger weight reduction. Analysis has additionally proven it to be nicely tolerated, inflicting few unintended effects.

Ann Rogers, MD, a bariatric surgeon and weight reduction skilled at Penn State Well being in Middletown, Pennsylvania, says that off-label drug use isn’t unusual. Which means a physician has determined that there’s a good purpose to make use of the drug for a function aside from its FDA-approved use.

“Medical doctors will discover out that sure drugs do sure issues successfully, after which will begin utilizing them for that function,” Dr. Rogers says. “A part of the explanation that topiramate will not be FDA-approved for weight reduction is that though analysis has discovered that it may be efficient, researchers don’t but absolutely perceive the way it achieves this weight reduction impact.”

A health care provider would possibly prescribe topiramate for weight reduction if different choices haven’t labored, have led to extreme unintended effects, or are too pricey for the affected person, she provides.

“All of it comes right down to what insurance coverage will cowl, what works, and what the affected person can afford,” Rogers says. “If a affected person additionally lives with migraine, a physician would possibly select topiramate to attempt to obtain each results with a single medicine.”

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