What Causes Cushing’s Syndrome?
Usually, there are two classes of what causes Cushing’s syndrome: exogenous (outdoors your physique) and endogenous (inside your physique).
Exogenous Cushing’s syndrome happens while you take steroid medicines referred to as glucocorticoids, which healthcare suppliers typically prescribe to assist scale back irritation.
Any type of glucocorticoid drug, whether or not it’s an injection, topical cream, or tablet, might result in Cushing’s syndrome over time, particularly if the doses are massive sufficient.
Then again, endogenous Cushing’s syndrome might happen when one thing causes your physique to make an excessive amount of cortisol by itself. Usually, your pituitary gland on the base of your mind releases a hormone referred to as adrenocorticotropic hormone (ACTH). That prompts your adrenal glands, situated on high of your kidneys, to provide cortisol.
Nonetheless, a tumor in your pituitary gland can produce an excessive amount of ACTH, which can result in Cushing’s syndrome. Equally, a tumor on the adrenal gland can straight lead an excessive amount of cortisol manufacturing, thereby inflicting Cushing’s syndrome. In uncommon instances, different neuroendocrine tumors situated in organs that don’t usually produce ACTH (such because the lungs or pancreas) might secrete ACTH and trigger Cushing’s syndrome.
