by bill barber
Good sources of resveratrol dosage information can be hard to come by. What you will see here is an accumulation of trustworthy recommendations. Some of the doses suggested by supplement companies are just too much. But first, you might like a little background information.
In 2003, the research groups of Howitz and Sinclair reported that resveratrol extending the lifespan of yeast, worms and fruit flies. In 2006, an Italian research group reported that the supplement extended the lifespan of short-lived fish.
However, the study also showed that there was an increased incidence of mortality among the younger fish. The theory is that the nutrient has a weak toxic activity, which can either stimulate defense mechanisms to extend lifespan or shorten it, probably depending on the overall health of the immune system.
In animal studies, researchers have found that a moderate dose has the same life-extension effect seen in calorie restriction. A group of human volunteers is currently participating in a long-term trial to find out if severe calorie restriction extends the average human lifespan in the same way that it does with primates.
The studies concerning calorie restriction have contributed to misleading resveratrol dosage information for weight loss. There has been no indication that the supplement is a weight loss aid. It is referred to as a “calorie restriction mimetic”. It seems to stimulate the same genetic activity found in animals on a calorie restricted diet. Whether or not that same effect will be seen in humans is, as yet, unknown.
Although no “serious” adverse effects have been seen in humans taking a single dose of 5000mg, there have been no studies concerning long-term daily use. One laboratory study showed that low doses extend the lifespan of heart cells, while large doses cause the death of those cells.
Some of the resveratrol dosage information from supplement manufacturers suggests the daily use of 500mg or more. That kind of dose will cause unwanted side effects, including diarrhea.
The supplements on the market today are derived from a medicinal root called Japanese Knotweed. The traditional use of the root was as a laxative. It contains emodin, a known laxative. When you read the labels of some supplements, you will see that the amount of emodin is listed. It is the manufacturers that suggest a high dose and do not list emodin that are the most misleading.
There is some reliable resveratrol dosage information from doctors of naturopathic medicine. To provide the preventative health benefits that may include a reduced risk of cancer, arthritis, type II diabetes and heart disease, they suggest 50mg per day for adults.
Because the nutrient is quickly changed by stomach acid into an unusable form, the supplement manufacturer should include an enteric coating. The coating dissolves when it reaches the upper intestine. The nutrient is released and passes easily through the intestinal wall and into the bloodstream.
A multi-nutritional supplement that includes the nutrient as an ingredient is a better choice than a single ingredient supplement. One nutrient can only do so much for your health.
Hopefully, the resveratrol dosage information provided here will help you choose a good supplement and improve your health. Maybe, you can even extend your life.